Philip Greulich

Philip Greulich



Research Interests

I like to think in a multidisciplinary way, and in my work I apply theoretical methods from statistical physics to other disciplines than physics. My main focus, though, is on stochastic processes used to model various biological systems, thereby improving the understanding of underlying mechanisms. Here I follow two directions: on the one hand understanding physical phenomena in biological systems (like phase transitions and critical phenomena) and on the other hand I use the modelling to infer underlying biological mechanisms (e.g. differentiation pathways, cell fate rules). For latter approach, I work together with leading biologists that perform experiments which yield high quality statistical data. Adjusting and fitting models to this data gives unexpected insights to the underlying biological phenomena.

My interests in particular are:

Statistical Physics:

Traffic phenomena in non-equilibrium transport systems

Biophysics:

Intracellular transport by motor proteins
Actin and microtubule dynamics
Protein synthesis; traffic of ribosomes
Antibiotic pharmacodynamics
Bacterial population dynamics
Evolution of drug resistances
Stochastic stem cell population dynamics

Publications:

P. Greulich, B. D. Simons
Dynamic heterogeneity as a strategy for stem cell self renewal
Under Review at Proc. Natl. Ac. Sci

J. Frede, P. Greulich, Tibor Nagy, B. D. Simons, P. J. Jones
The cellular basis of oesophageal tumour growth
Under Review at Nature Cell Biology (2016)

P. Greulich, M. Scott, M. R. Evans, R. J. Allen
Growth-dependent bacterial susceptibility to ribosome-targeting antibiotics
Mol. Syst. Biol. 11, p. 796 (2015)

M. P. Alcolea, P. Greulich, A. Wabik, J. Frede, B. D. Simons, P. H. Jones
Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change
Nature Cell Biology 16, p. 615 (2014)

P. Greulich, B. Waclaw and R. J. Allen
Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution of Drug-Resistant Cells
Phys. Rev. Lett. 109, p. 088101 (2012)

P. Greulich, L. Ciandrini, M. C. Romano and R. J. Allen
Mixed population of competing totally asymmetric simple exclusion processes with a shared reservoir of particles
Phys. Rev. E 85, p. 011142 (2012)

P. Greulich and L. Santen
Boundary-induced orientation of dynamic filament networks and vesicle agglomerations
Phys. Rev. E 84, p. 060902(R) (2011)

P. Greulich and L. Santen
Active transport and cluster formation on 2D networks
Eur. Phys. J. E 32 p. 191 (2010)

P. Greulich and A. Schadschneider
Disordered driven lattice gases with boundary reservoirs and Langmuir kinetics
Phys. Rev. E 79 p.031107-1 - 031107-14 (2009)

D. Chowdhury, A. Basu, A. Garai, P. Greulich, K. Nishinari, A. Schadschneider, T. Tripathi
Intra-cellular traffic: bio-molecular motors on filamentary tracks
European Phys. J. B 64 p.593-600 (2008)

P. Greulich and A. Schadschneider
Single-bottleneck approximation for driven lattice gases with disorder and open boundary conditions
Journal of Statistical Mechanics: Theory and Experiment p. 04009.1-04009.23 (2008)

P. Greulich and A. Schadschneider
Phase diagram and edge effects in the ASEP with Bottlenecks
Physica A 387 p. 1972-1986 (2008)

P. Greulich, A. Garai, K. Nishinari, A. Schadschneider, D. Chowdhury
Intra-cellular transport by single-headed kinesin KIF1A: effects of single-motor mechano-chemistry and steric interactions
Phys. Rev. E 75 p. 041905-1 - 041905-17 (2007)

In Conference Proceedings:

D. Chowdhury, A. Garai, P. Greulich, K. Nishinari, A. Schadschneider, T. Tripathi, J.-S. Wang
From CA to Gene Expression: Machines and Mechanisms
Lecture Notes In Computer Science: ACRI 2008

P. Greulich and A. Schadschneider
Statistical Properties of Disordered Driven Lattice Gases with Open Boundaries
Traffic and Granular Flow 2007

K. Nishinari, Y. Kanayama, Y. Okada, P. Greulich, A. Schadschneider, D. Chowdhury
Stochastic Modelling and Experiments on Intra-Cellular Transport of Single-Headed Molecular Motors
Traffic and Granular Flow 2005

CV

Positions

Jan 2013 - Now: Postdoctoral Research Fellow (DFG) with Benjamin Simons at Cavendish Laboratory, University of Cambridge, UK
Sept 2010 - Dec 2012: Postdoctoral Research fellow (DAAD) with Rosalind Allen and Martin Evans at School of Physics and Astronomy, University of Edinburgh, UK
Oct 2007 - Aug 2010: Research Assistant (as PhD student) with Ludger Santen at Fachgruppe Theoretische Physik, University of the Saarland, Germany
June 2006 - Sept 2007: Research Assistant (as PhD student) with Andreas Schadschneider at Institute for Theoretical Physics, University of Cologne, Germany

Education

March 2010: PhD in Physics, University of the Saarland
July 2006: Diploma in Physics, University of Cologne
April 2003 - July 2006: Studies of Physics at University of Cologne
Oct 2000 - March 2003: Studies of Physics at University of Heidelberg

List of useful sites

  1. The Theory of Living Matter initiative

Last modified: Su Mar 29 2015